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Transformed DLBCL usually add CDKN2A deletions and MYC translocations or amplifications along with the genomic alterations by now existing in the original CLL, but absence the prevalent mutations noticed in Main DLBCL indicating they may well correspond to another biological class.80 Richter transformation also happens in people handled with BTK inhibitors. These tumors tend not to commonly acquire BTK or PLCG2 mutations but, if these were present in the original CLL, subclones could emerge with added impartial mutations.89,ninety
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